Anisotropic layered semiconductors have attracted significant interest due to the huge possibility of bringing new functionalities to thermoelectric, electronic and optoelectronic devices. Currently, most reports on anisotropy have concentrated on black phosphorus and ReS2, less effort has been contributed to other layered materials. In this work, a large scale of two-dimensional (2D) orthorhombic SnS flakes has been successfully synthesized via a simple physical vapor deposition method. Angular-dependent Raman spectroscopy indicated that the orthorhombic SnS flakes possess strong anisotropic Raman response. Under parallel-polarization configuration, the peak intensity of Ag (190.7 cm-1) Raman mode reaches the maximum when incident light polarization is parallel to armchair direction of the 2D SnS flakes, which strongly suggests that the Ag (190.7 cm-1) mode can be used to determine the crystallographic orientation of the 2D SnS. In addition, temperature-dependent Raman characterization confirmed that the 2D SnS flakes have a higher sensitivity to temperature than graphene, MoS2 and black phosphorus. These results are useful for future studies of the optical and thermal properties of 2D orthorhombic SnS.