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Radical Addition of Hydrazones by alpha-Bromo Ketones to Prepare 1,3,5-Trisubstituted Pyrazoles via Visible Light Catalysis
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Update time: 2016-07-14
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A novel efficient tandem reaction of hydrazones and alpha-bromo ketones is reported to prepare 1,3,5-trisubstituted pyrazoles by visible light catalysis. In this system, the monosubstituted hydrazones show wonderful reaction activity with alkyl radicals, generated from alpha-bromo ketones. A radical addition followed by intramolecular cyclization affords the important pyrazole skeleton in good to excellent yields. This efficient strategy with mild condition and wide group tolerance provides a potential approach to the 1,3,5-trisubstituted pyrazoles. 

J. Org. Chem., 2016 

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