Laboratory of Biomimetic Intelligent Interface Science
About
Dr. ZHEN Wenyao is a national high-level young talent and a recipient of the National Excellent Young Scientists Fund (Overseas).
Dr. ZHEN Wenyao earned her Ph.D. in 2021 from the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (School of Applied Chemistry and Engineering, University of Science and Technology of China). In 2022, she conducted postdoctoral research in the Department of Chemistry and the Department of Radiation and Cellular Oncology at the University of Chicago, USA. In 2024, she joined the Yong Loo Lin School of Medicine at the National University of Singapore for postdoctoral research. In 2025, she returned to China and joined the Biomimetic Intelligent Interface Science Center at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, becoming a member of the research team led by Prof. WANG Shutao.
Her long-term research focuses on the molecular chemical nature of biointerface interactions and their dynamic regulation mechanisms. Centered on the design and development of biomimetic intelligent materials, she systematically investigates the intrinsic relationship between molecular structure and biointerface regulatory functions, and further develops biomimetic intelligent material systems with controllable regulation and responsive properties. These systems are applied for theoretical validation and practical expansion in complex biological environments and the diagnosis and treatment of major diseases.
Up to now, a total of 47 academic papers have been published, among which 243 SCI papers have been published as the first or corresponding author, including 4 in J. Am. Chem. Soc., 3 in Adv. Mater., 4 in Angew. Chem. Int. Ed., Chem. Soc. Rev. and other top international journals; 3 patents have been authorized.
Research Areas
Biomimetic Material Synthesis and Biointerface Regulation for Age-Related Chronic Diseases
Publications
[1] Rebeka Rita Reszegi; Wenyao Zhen*; Xiaoyuan Chen*; Jingjing Zhang*. Switchable and Biodegradable Nanostructures for Safe and Precise Tumor Diagnostics, Chemical Society Reviews, 2026, DOI：10.1039/d5cs00925a.
[2] Wenyao Zhen‡; Wang-Kang Han‡; Tianzhi Zhao; Rebeka Rita Reszegi; Zhenni Wei; Zhiguo Gu*, Jingjing Zhang*, Xiaoyuan Chen*. MSA-2 Loaded Three-Dimensional Metal Covalent Organic Framework for Synergistic Radiosensitization and Innate Immune Activation, Journal of the American Chemical Society, 2026, 148(8), 8393-8404.
[3] Wenyao Zhen‡; Yingjie Fan‡; Tomas Germanas; Langston Tillman; Jinhong Li; Abigail L. Blenko; Ralph R. Weichselbaum; Wenbin Lin*. Digitonin-Loaded Nanoscale Metal-Organic Framework for Mitochondria-Targeted Radiotherapy-Radiodynamic Therapy and Disulfidptosis. Advanced Materials, 2025, 37(52): 2405494.
[4] Wenyao Zhen‡; Ziwan Xu‡; Yibin Mao‡; Caroline McCleary; Xiaomin Jiang; Ralph R. Weichselbaum*; Wenbin Lin*. Nanoscale Mixed-Ligand Metal-Organic Framework for X-ray Stimulated Cancer Therapy. Journal of the American Chemical Society, 2024, 146(48): 33149-33158.
[5] Wenyao Zhen‡; Dong Won Kang‡; Yingjie Fan; Zitong Wang; Tomas Germanas; Geoffrey T. Nash; Qijie Shen; Rachel Leech; Jinhong Li; Gregory S. Engel; Ralph R. Weichselbaum; Wenbin Lin*. Simultaneous Protonation and Metalation of a Porphyrin Covalent Organic Framework Enhance Photodynamic Therapy. Journal of the American Chemical Society, 2024, 146(24): 16609-16618.
[6] Wenyao Zhen‡; Tomas Germanas‡; Ralph R. Weichselbaum; Wenbin Lin*, Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment, Angewandte Chemie International Edition, 2024, 136(46): e202412844.
[7] Ziwan Xu‡; Wenyao Zhen‡; Caroline McCleary; Taokun Luo; Xiaomin Jiang; Cheng Peng; Ralph R. Weichselbaum; Wenbin Lin*. Nanoscale Metal-Organic Framework with An X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy. Journal of the American Chemical Society, 2023, 145(34): 18698-18704.
[8] Wenyao Zhen; Ralph R. Weichselbaum; Wenbin Lin*. Nanoparticle‐Mediated Radiotherapy Remodels the Tumor Microenvironment to Enhance Antitumor Efficacy. Advanced Materials, 2023, 35(21): 2206370.
[9] Wenyao Zhen; Yang Liu; Shangjie An; Xiue Jiang*. Glutathione‐Induced In Situ Michael Addition between Nanoparticles for Pyroptosis and Immunotherapy. Angewandte Chemie International Edition, 2023, 62(20): e202301866
[10] Wenyao Zhen; Shangjie An; Shuqi Wang; Wenxue Hu; Yujie Li; Xiue Jiang*; Jinghong Li*. Precise Subcellular Organelle Targeting for Boosting Endogenous‐Stimuli‐Mediated Tumor Therapy. Advanced Materials, 2021, 33(51): 2101572.
Awards and Honors
1. 2023, CAIA Award (First Prize) of the China Association for Instrumental Analysis
2. 2023, Jingbo Science and Technology Award, awarded by the Chinese Chemical Society and Shandong Jingbo Holding Group Co., Ltd.
3. 2021, President's Special Award of the Chinese Academy of Sciences
4. 2021, Outstanding Graduate of Higher Education Institutions in Anhui Province
5. 2020, Oxford Instruments Tomorrow Star Scholarship, awarded by the University of Science and Technology of China and Oxford Instruments (Shanghai) Co., Ltd.
6. 2020, National Scholarship for Doctoral Students and National Scholarship for Master's Students
7. 2018, National Scholarship for Doctoral Students and National Scholarship for Master's Students
