The research group headed by Prof. TANG Fangqiong of Technical Institute of Physics and Chemistry, Chinese Academy of Sciences has developed a new drug delivery system for cancer therapy using silica nanorattle as drug carrier.

To solve the nonspecific toxicity anti-tumor drugs, they designed silica nanorattle with high drug loading and controlled drug release as drug carrier. For liver cancer therapy, the silica nanorattleencapsulated docetaxel showed higher therapeutic efficacy and lower systematic toxicity compared with current clinical formulation of Taxotere.The drug carrier itself had high biocompatibility with single and repeated dose administration and can be excrete from the body.These findings are a great stride for inorganic nanoparticle-based drug delivery systems, and have potentials to revolutionize the diagnosis and treatment of cancer.

The works published onACS Nano and Biomaterials weresupported by National High-tech R&D Program of China (863 Program) and National Natural Science Foundation of China.

For the abstract of the papers published, please visit:

http://pubs.acs.org/doi/abs/10.1021/nn100918a

http://dx.doi.org/10.1016/j.biomaterials.2010.10.035

Figure 1  Silica nanorattle as drug delivery system for Liver Cancer Therapy with Low Toxicity and High Efficacy

Figure 2  Single and Repeated Dose Toxicity of Silica Nanorattle

(Image by TIPC,CAS)