The preparation of functionalized bis-ureidopyrimidinones (Bis-UPy) through the thiol-yne reaction is described. Various Bis-UPys with different functional groups were synthesized by using the readily available functionalized alkynes and UPy-thiol to affirm the simplicity and versatility of the methodology.Chemistry - A European Journal, 2014 Illustration for synthesis of bis-ureidopyrimidinones by disulfide-thiol chemistry and thiol-yne reaction |