Nano-bio integrated technology group is devoted to research and develop BioMEMS devices for biomedical purpose, taking advantage of the nanometer technology, biotechnology and advanced micro processing technology. The Nano-bio integrated technology group is primarily concerned with the exploitation of microneedle transdermal delivery chips, immunochips and micro-fluidic chips.

At present, the study on microneedle transdermal delivery chips has achieved initial success. By penetrating the great barrier imposed by skin’s outer stratum corneum layer, these microneedles facilitate the diffusion of drug molecules into the systemic circulation. Therefore, microneedles provide a novel means to transport molecules into the skin, with the characteristics of both subcutaneous injections and transdermal patches. The best feature of this technology is to deliver macro-molecules and nanometer particulates in vivo in a painless way.

Our microneedle products have reached the advanced level in China, placing in the forefront of the world. Moreover, we are the first to receive a registered certificate of medical device for the transdermal delivery of microneedles in the world. At present, our group focuses on the exploitation of medicine diffusion technology based on microneedles to satisfy the demand of the world medical market.

Another part of our research is to study and develop immuno biochips of magnetic tunnel effect, which could find wide application in clinical diagnosis and food testing fields. This project has been supported in the National High Technology 863 R&D Plan.

Perpetual Members:
Yunhua Gao, PhD, Professor, Organic Chemistry, 1996 Okayama University, Janpan
Fang Li , Master , Practical Professor, Pharmacology, 2006 Southwest University & Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College

Temportary Members:
Bai Xu, Visiting Professor , Microsystem, Insitutite for Material Research, The State University of New York, Albany, Senior Research Scientist
Chao Lin, Visiting Professor , Biophysics, VIP of MESTECH Electronics CO., LTD
Yuqin Qiu, Pharmacy, Ph.D. Students, enrolled in IPC of CAS in 2004
Yan Wu, Pharmacy, Ph.D. Students, enrolled in IPC of CAS in 2005
Suohui Zhang , Pharmacy, Ph.D. Students, enrolled in IPC of CAS in 2005
Guangjiong Qin, Analytic Chemistry, Ph.D. Students, enrolled in IPC of CAS in 2005
Kejia Hu, Chiemistry, Ph.D. Students, enrolled in IPC of CAS in 2006
Wenwen Zhou, Physics, Ph.D. Students, enrolled in IPC of CAS in 2006
Shuang Li, Pharmacy, Ph.D. Students, enrolled in IPC of CAS in 2006
Jie Lian, Chemistry, Ph.D. Students, enrolled in IPC of CAS in 2007
Hao Wang, Medical Engineering, Ph.D. Students, enrolled in IPC of CAS in 2007

Dr. Gao’s Contact Information
Add: 2 Bei Yi Tiao, Zhong Guan Cun, Beijing 100080, China
Tel: +86-01-82543581
Fax：+86-01-82543581
E-mail:yhgao@mail.ipc.ac.cn
Web:

1. A selective colorimetric chemosensor based on Calixarene framework for lanthanide ions-Dy3+ and Er3+ , Zhi Liang, Zhilian Liu and Yunhua Gao*, Tetrahedron Letters, In Press, Accepted Manuscript, Available online 18 March 2007.

2. Synthesis, Characterization and Photochromic Studies of Three Novel Calix[4]arene-Schiff Bases, Zhi Liang, Zhilian Liu and Yunhua Gao*, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, In Press, Accepted Manuscript, Available online 30 January 2007.

3. Functionalization of chitosan with 3,4-dihydroxybenzoic acid or the adsorption/collection of uranium in water samples and its determination by inductively coupled plasma-mass spectrometry, Akhmad Sabarudin, Mitsuko Oshima,∗, Toshio Takayanagi, Lukman Hakim, Koji Oshita, Yun Hua Gao, Shoji Motomizu, Analytica Chimica Acta, Volume 581, Issue 2, 4 January 2007, Pages 214-220.

4. A new fluorescent chemosensor for copper (II) and molecular switch controlled by light, Zhi Liang, Zhilian Liu, Lin Jiang and Yunhua Gao*, Tetrahedron Letters, Volume 48, Issue 9, 26 February 2007, Pages 1629-1632.

5. A selective colorimetric chemosensor for lanthanide ions, Zh. Liu, L. Jiang, Zh. Liang and Y. Gao*, Tetrahedron, 62, 2006, 3214–3220.

6. Modeling of transdermal drug delivery with a microneedle array, Y-G Lv, J Liu, Y-HGao and B Xu, J. Micromech. Microeng. 16, 2006, 1–10.

7. Y. Xie, B. Xu and Y. Gao*, “Controlled transdermal delivery of model drug compounds by MEMS microneedle array”, Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 1, p. 184-190,2005.

8, Magnetically-Actuated Micromixing on Array-Pattern Microfluidic Chip for Immunoassay of TSH，Chengwu Li,  Yongning Wang,  Yunhua Gao1*,  XiaoYing Guo and Zhongze Gu， Journal of Nanoscience and Nanotechnology. 2005，1297-1300.

9, An Artificial Aspartic Proteinase System, Lin Jiang, Zhilian Liu, Zhi Liang, and Yunhua Gao*, Bioorganic & Medicinal Chemistry, 13, 2005, 3673-80.

10，Photo-switching molecular devices based on metal-ionic recognition, Zhilian Liu, Lin Jiang , Zhi Liang and Yunhua Gao*, Tetrahedron Letters, 46, 2005, 885-887.

Industrialization:
The patent of transdermal microneedle array patch has been transferred to the local enterprise and we actively render assistance to them in promoting the industrialized operation of microneedle transdermal delivering technology.