Through a modular ROMP (ring-opening metathesis polymerization) strategy, a random copolymer with anti-thrombotic activity and imaging capability has been constructed from RGD, rhodamine B and PEG modified norbornene monomers. As we expected, these tri-component polynorbornenes exhibit significant enhancement in anti-thrombotic efficacy and bioavailability in vivo. 

 Chem. Commun.,2014

Design of RGD-modified copolymers for targeting the GPIIb/IIIa receptor on activated platelets involved in thrombotic events.

The preparation of PNB-RGDSx-co-RhBy-co-mPEGz random copolymers.