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A Novel Azopyridine-based Ru (II) Complex with GSH-responsive DNA Photobinding Ability
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Update time: 2015-05-27
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A novel azopyridine-based Ru(II) complex [Ru(bpy)2(L1)2]2+ (bpy = 2,2’-bipyridine, L1 = 4,4’-azopyridine) was designed and synthesized as a potential glutathione (GSH)-responsive photoactivated chemotherapy (PACT) agent, the DNA covalent binding capability of which can be only activated after GSH reduction and visible light irradiation. 

Chem. Commun., 2015 

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